Wyss InstituteAnti-aging – Wyss Institute

Alex Plesa on Reversing Aging

Jessica Leff — Thu, 30 May 2024 13:00:18 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. Most people believe that declining health as we age is an unfortunate, inevitable fact of life – but not Alex Plesa. He thinks the reason we think we can’t change it is because we don’t…

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Ichor: Reversing Aging

Jessica Leff — Wed, 01 May 2024 10:47:33 +0000

More than 150,000 people die each day across the globe, about two-thirds of them from age-related causes like cancer, neurodegenerative diseases, and cardiovascular disease. If the process of aging could be slowed or reversed, the incidence of these conditions would be dramatically reduced, and more humans would live longer, healthier lives. However, aging is a complex process involving multiple…

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Clearing a path for non-invasive muscle therapy for the elderly

Jessica Leff — Wed, 22 Mar 2023 17:57:17 +0000

By Benjamin Boettner (BOSTON) — Mechanotherapy, the concept of using mechanical forces to stimulate tissue healing, has been used for decades as a form of physical therapy to help heal injured muscles. However, the biological basis and optimal settings for mechanotherapies are still poorly understood, especially with respect to elderly patients. Given the well-known decline in healing ability…

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Wasting muscles built back better

Mariel Schoen — Mon, 14 Nov 2022 15:55:28 +0000

By Benjamin Boettner (BOSTON) — Muscles waste as a result of not being exercised enough, as happens quickly with a broken limb that has been immobilized in a cast, and more slowly in people reaching an advanced age. Muscle atrophy, how clinicians refer to the phenomenon, is also a debilitating symptom in patients suffering from neurological disorders, such as amyotrophic lateral sclerosis (ALS)…

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Landing therapeutic genes safely in the human genome

Jessica Leff — Mon, 24 Jan 2022 15:57:27 +0000

By Benjamin Boettner (BOSTON) — Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called “genomic safe harbors (GSHs).” These are landing sites in the human genome able to safely accommodate new therapeutic genes without causing other, unintended changes in a cell’s…

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Denitsa Milanova on MRBL – Gene Therapy for Skin Rejuvenation

Jessica Leff — Thu, 25 Mar 2021 14:45:11 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as scientists, and their collaborations at the Wyss Institute and beyond. When Denitsa Milanova was an engineering graduate student at Stanford University, she started taking business classes on the side to learn more about herself and her interests. She ended up with…

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MRBL: Next-Generation Gene Therapy for Molecular Skin Rejuvenation

admin — Sat, 13 Mar 2021 04:40:00 +0000

The skin is the largest organ in the body, and carries out multiple vital functions, including protective barrier functions against the loss of moisture and mechanical, UV and other injuries, immune defense functions, as well as sensory functions. For maintaining its integrity and multifaceted performances, skin relies on a range of different cell types that compose and support its layered…

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Improving Canine Healthspan

Jessica Leff — Thu, 06 Feb 2020 16:21:59 +0000

A Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University…

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Rejuvenate Bio launches to help dogs live longer, healthier lives

Jessica Leff — Thu, 06 Feb 2020 15:57:29 +0000

By Lindsay Brownell (BOSTON) — The Wyss Institute for Biologically Inspired Engineering at Harvard University announced today that Rejuvenate Bio has secured an exclusive worldwide license from the Harvard Office of Technology Development to commercialize a gene therapy technology developed at the Wyss Institute and Harvard Medical School (HMS) to prevent and treat several age-related diseases…

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Combination gene therapy treats multiple age-related diseases in mice

Jessica Leff — Mon, 04 Nov 2019 19:56:01 +0000

By Lindsay Brownell (BOSTON) — As we age, our bodies tend to develop diseases like heart failure, kidney failure, diabetes, and obesity, and the presence of any one disease increases the risk of developing others. In traditional drug development, a drug usually only targets one condition, largely ignoring the interconnectedness of age-related diseases, such as obesity, diabetes…

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