Wyss InstituteHeart Disease – Wyss Institute

Innovative tissue engineering: ESCAPE, a pioneering new method explained

Jessica Leff — Wed, 11 Dec 2024 16:00:31 +0000

By Boston University Communications (BOSTON) — When it comes to the human body, form and function work together. The shape and structure of our hands enable us to hold and manipulate things. Tiny air sacs in our lungs called alveoli allow for air exchange and help us breath in and out. And tree-like blood vessels branch throughout our body, delivering oxygen from our head to our toes.

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ESCAPE Bioengineering

Jessica Leff — Wed, 11 Dec 2024 16:00:06 +0000

A research team at the Wyss Institute and Boston University has developed ESCAPE, the first method that enables the engineering of tissues across multiple length scales, ranging from the diameter of a cell to the cm scale of a heart valve. Credit: Wyss Institute at Harvard University…

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CRISPR’s Impact, Today

Mariel Schoen — Mon, 21 Oct 2024 12:00:08 +0000

By Seth Kroll (BOSTON) — In the not-so-distant past, CRISPR, the revolutionary gene-editing technology, was discovered as a defense system protecting bacteria against viruses. Today, with the persistence and ingenuity of many scientists, it is no longer just the subject of fascinating academic research papers and speculative discussions on its future usefulness for medicine.

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Fiber-infused ink enables 3D-printed heart muscle to beat

Jessica Leff — Tue, 08 Aug 2023 14:30:44 +0000

By Kat J. McAlpine / SEAS Communications (BOSTON) – Over the last decade, advances in 3D printing have unlocked new possibilities for bioengineers to build heart tissues and structures. Their goals include creating better in vitro platforms for discovering new therapeutics for heart disease, the leading cause of death in the United States, responsible for about one in every five deaths…

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Wyss Institute promotes Christopher Chen to a Core Faculty member and appoints Ellen Roche and Michael Springer as new members of its Associate Faculty

Jessica Leff — Mon, 31 Jul 2023 14:58:15 +0000

By Benjamin Boettner (BOSTON) — Christopher Chen, M.D., Ph.D. has had a long and prolific past at the Wyss Institute and its 3D Organ Engineering Initiative as an Associate Faculty member, and based on his deep commitment to the Institute and its translational mission, he has now been promoted to become one of the Institute’s 12 Core Faculty members. The Wyss Institute is also excited to welcome…

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New, spun-fiber heart valve is a step closer to patients

Jessica Leff — Wed, 07 Jun 2023 14:55:18 +0000

By Lindsay Brownell (BOSTON) — Strep throat is a common and treatable childhood disease in the US, but in less wealthy countries, children afflicted with strep can develop rheumatic fever, in which runaway inflammation attacks the body’s tissues. Rheumatic fever often damages the valves of the heart, causing rheumatic heart disease that can lead to serious health problems…

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A major step forward for organ biofabrication

Jessica Leff — Wed, 13 Jul 2022 14:00:18 +0000

By Leah Burrows / SEAS Communications (CAMBRIDGE, Mass.) ‑ Heart disease — the leading cause of death in the U.S. — is so deadly in part because the heart, unlike other organs, cannot repair itself after injury. That is why tissue engineering, ultimately including the wholesale fabrication of an entire human heart for transplant, is so important for the future of cardiac medicine.

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Harvard Wyss Institute’s eRapid multiplexed biosensor technology licensed to StataDX to enable new diagnostics for neurological, cardiovascular, and renal diseases

Mariel Schoen — Mon, 27 Jun 2022 12:58:22 +0000

By Benjamin Boettner (BOSTON) — Today the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cambridge-based StataDX Inc. announced that the Wyss Institute’s affinity-based, multiplexed, electrochemical sensing technology, eRapid, has been licensed to the startup. The license, coordinated by Harvard’s Office of Technology Development (OTD)…

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Getting to the heart of engineering a heart

Jessica Leff — Wed, 08 Jun 2022 14:58:05 +0000

By Benjamin Boettner (BOSTON) — Heart disease is the leading cause of death among adults and infants in the U.S. with about 659,000 people dying from heart disease each year, every one in four deaths. Among the many patients with a critical heart condition, about 3,500 are waiting for a heart transplant. Many of them will wait for more than six months, and for some of them time will run out…

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Biohybrid fish made from human cardiac cells swims like the heart beats

Jessica Leff — Fri, 11 Feb 2022 17:23:04 +0000

By Leah Burrows/SEAS Communications (CAMBRIDGE, Mass.) – Harvard University researchers, in collaboration with colleagues from Emory University, have developed the first fully autonomous biohybrid fish from human stem-cell derived cardiac muscle cells. The artificial fish swims by recreating the muscle contractions of a pumping heart, bringing researchers one step closer to developing a more…

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