Wyss InstituteKidney Disease – Wyss Institute

Innovative tissue engineering: ESCAPE, a pioneering new method explained

Jessica Leff — Wed, 11 Dec 2024 16:00:31 +0000

By Boston University Communications (BOSTON) — When it comes to the human body, form and function work together. The shape and structure of our hands enable us to hold and manipulate things. Tiny air sacs in our lungs called alveoli allow for air exchange and help us breath in and out. And tree-like blood vessels branch throughout our body, delivering oxygen from our head to our toes.

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ESCAPE Bioengineering

Jessica Leff — Wed, 11 Dec 2024 16:00:06 +0000

A research team at the Wyss Institute and Boston University has developed ESCAPE, the first method that enables the engineering of tissues across multiple length scales, ranging from the diameter of a cell to the cm scale of a heart valve. Credit: Wyss Institute at Harvard University…

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CRISPR’s Impact, Today

Mariel Schoen — Mon, 21 Oct 2024 12:00:08 +0000

By Seth Kroll (BOSTON) — In the not-so-distant past, CRISPR, the revolutionary gene-editing technology, was discovered as a defense system protecting bacteria against viruses. Today, with the persistence and ingenuity of many scientists, it is no longer just the subject of fascinating academic research papers and speculative discussions on its future usefulness for medicine.

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Wyss Institute promotes Natalie Artzi to its Core Faculty and appoints Di Feng as an Associate Faculty member

Jessica Leff — Mon, 12 Aug 2024 13:15:25 +0000

By Benjamin Boettner (BOSTON) — Natalie Artzi, Ph.D., joined the ranks of the Wyss Institute’s now 12 Core Faculty members after only two years as an Associate Faculty member. Artzi’s promotion reflects her exceptional commitment to the Institute’s mission and the deep engagements and collaborations she has initiated within its technology development community. The Wyss Institute also warmly…

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Alex Plesa on Reversing Aging

Jessica Leff — Thu, 30 May 2024 13:00:18 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. Most people believe that declining health as we age is an unfortunate, inevitable fact of life – but not Alex Plesa. He thinks the reason we think we can’t change it is because we don’t…

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In a first, genetically edited pig kidney is transplanted into human

Mariel Schoen — Fri, 22 Mar 2024 21:16:08 +0000

By Mass General Brigham Communications In a first-of-its-kind medical procedure, Harvard Medical School physician-scientists at Massachusetts General Hospital have transplanted a genetically edited pig kidney into a human. While many unknowns remain about the viability of the newly transplanted organ and the patient’s long-term health, the procedure — made possible in part by scientific…

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Adding immunity to human kidney-on-a-chip advances cancer drug testing

Seth Kroll — Wed, 23 Aug 2023 14:57:37 +0000

By Benjamin Boettner (Boston) — A growing repertoire of cell and molecule-based immunotherapies is offering patients with indomitable cancers new hope by mobilizing their immune systems against tumor cells. An emerging class of such immunotherapeutics, known as T cell bispecific antibodies (TCBs), are of growing importance with several TCBs that the U.S. Food and Drug Administration (FDA)…

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Harvard Wyss Institute’s eRapid multiplexed biosensor technology licensed to StataDX to enable new diagnostics for neurological, cardiovascular, and renal diseases

Mariel Schoen — Mon, 27 Jun 2022 12:58:22 +0000

By Benjamin Boettner (BOSTON) — Today the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cambridge-based StataDX Inc. announced that the Wyss Institute’s affinity-based, multiplexed, electrochemical sensing technology, eRapid, has been licensed to the startup. The license, coordinated by Harvard’s Office of Technology Development (OTD)…

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Harvard University licenses kidney engineering technology to Trestle Biotherapeutics to facilitate new kidney replacement therapies

Jessica Leff — Tue, 22 Feb 2022 18:57:14 +0000

By Benjamin Boettner (BOSTON/CAMBRIDGE, Mass.) — A newly launched startup is building upon innovations developed over several years at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering & Applied Sciences (SEAS), and Brigham and Women’s Hospital (Brigham) to engineer functional kidney tissue for renal repair and…

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Interrogator: Human Organ-on-Chips

Jessica Leff — Mon, 27 Jan 2020 16:00:40 +0000

This video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips in long-term studies.

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