Wyss InstituteLiver Disease – Wyss Institute

Innovative tissue engineering: ESCAPE, a pioneering new method explained

Jessica Leff — Wed, 11 Dec 2024 16:00:31 +0000

By Boston University Communications (BOSTON) — When it comes to the human body, form and function work together. The shape and structure of our hands enable us to hold and manipulate things. Tiny air sacs in our lungs called alveoli allow for air exchange and help us breath in and out. And tree-like blood vessels branch throughout our body, delivering oxygen from our head to our toes.

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ESCAPE Bioengineering

Jessica Leff — Wed, 11 Dec 2024 16:00:06 +0000

A research team at the Wyss Institute and Boston University has developed ESCAPE, the first method that enables the engineering of tissues across multiple length scales, ranging from the diameter of a cell to the cm scale of a heart valve. Credit: Wyss Institute at Harvard University…

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Alex Plesa on Reversing Aging

Jessica Leff — Thu, 30 May 2024 13:00:18 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. Most people believe that declining health as we age is an unfortunate, inevitable fact of life – but not Alex Plesa. He thinks the reason we think we can’t change it is because we don’t…

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Sangeeta Bhatia appointed as a Foreign Fellow of the Australian Academy of Technological Sciences and Engineering

Jessica Leff — Mon, 16 Oct 2023 14:58:00 +0000

(BOSTON) – A Nobel prize laureate, leaders tackling the Aussie engineering shortage, climate change innovators, research translation superstars, and Aboriginal and Torres Strait Islander STEM education champions are among the distinguished cohort of Fellows elected to the Australian Academy of Technological Sciences and Engineering (ATSE) this year. The 2023 new ATSE Fellows have been chosen for…

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How do we make safer and more effective drugs?

Jessica Leff — Mon, 12 Jun 2023 15:14:20 +0000

Wyss researchers are using an ever-growing number of human tissue-mimicking Organ Chips to improve and accelerate the drug development process for a wide number of unmet diseases – and understand what causes them to erupt. More recently, they added a human Vagina Chip and personalized Barrett’s esophagus Chip to their arsenal, and created in vitro models of inflammatory bowel disease in children…

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From classmates to co-founders

Mariel Schoen — Mon, 24 Apr 2023 13:30:17 +0000

Wyss Associate Faculty members Chris Chen and Sangeeta Bhatia are long-time friends and colleagues. They met as graduate students in the Harvard–MIT Program in Health Sciences and Technology, got their M.D.s together at Harvard Medical School, and collaborated on projects once they started their own labs – Chen working on angiogenesis at the Johns Hopkins University and Bhatia working on liver…

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Luba Perry on Engineering Vascularized Tissue

Jessica Leff — Wed, 23 Jun 2021 15:00:25 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as scientists, and their collaborations at the Wyss Institute and beyond. When Luba Perry was first exposed to the field of tissue engineering at a job in industry, she was immediately hooked. Building something from nothing and seeing it flourish in the body was…

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Interrogator: Human Organ-on-Chips

Jessica Leff — Mon, 27 Jan 2020 16:00:40 +0000

This video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips in long-term studies.

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Human Body-on-Chip platform enables in vitro prediction of drug behaviors in humans

Jessica Leff — Mon, 27 Jan 2020 15:58:57 +0000

(BOSTON) — Drug development is an extremely arduous and costly process, and failure rates in clinical trials that test new drugs for their safety and efficacy in humans remain very high. According to current estimates, only 13.8% of all tested drugs demonstrate ultimate clinical success and obtain approval by the Food and Drug Administration (FDA). There are also increasing ethical concerns…

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Sangeeta Bhatia Joins Wyss Institute

Jessica Leff — Tue, 13 Nov 2018 15:58:38 +0000

By Lindsay Brownell (BOSTON) — Sangeeta Bhatia knew in her teens that she wanted to work on improving human health and, after studying biomedical engineering at Brown University, took her first job at a pharmaceutical company. That foray lasted less than a year, and sent her “running back to grad school” to recover her connection to what she calls “the human interface.” But as her academic…

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