Wyss InstituteAging – Wyss Institute

Ichor: Reversing Aging

Jessica Leff — Wed, 01 May 2024 10:47:33 +0000

More than 150,000 people die each day across the globe, about two-thirds of them from age-related causes like cancer, neurodegenerative diseases, and cardiovascular disease. If the process of aging could be slowed or reversed, the incidence of these conditions would be dramatically reduced, and more humans would live longer, healthier lives. However, aging is a complex process involving multiple…

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The Wyss Institute’s 2023-2024 Validation Projects

Seth Kroll — Thu, 19 Oct 2023 14:47:13 +0000

Each year we name a class of Validation Projects whose teams receive dedicated funding, business development support, and additional resources to advance their technologies towards commercialization. Over the course of the year, project teams pursue initial use-cases for their technologies that have the potential for significant positive impact. They also collaborate with key opinion leaders…

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Clearing a path for non-invasive muscle therapy for the elderly

Jessica Leff — Wed, 22 Mar 2023 17:57:17 +0000

By Benjamin Boettner (BOSTON) — Mechanotherapy, the concept of using mechanical forces to stimulate tissue healing, has been used for decades as a form of physical therapy to help heal injured muscles. However, the biological basis and optimal settings for mechanotherapies are still poorly understood, especially with respect to elderly patients. Given the well-known decline in healing ability…

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Reimagine the World: Volume 1

Jessica Leff — Thu, 22 Sep 2022 13:58:05 +0000

Four Wyss Institute scientists, Mariana Garcia-Corral, Pawan Jolly, Megan Sperry, and Mike Super, share how they would Reimagine the World and the personal stories that fuel their passion for the work they are doing. We’d love to hear how you would Reimagine the World! Please visit the following link to share your ideas: https://wyss.typeform.com/to/o9xM7cG1 Credit: Wyss Institute at Harvard…

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Reimagine the World

Jessica Leff — Thu, 22 Sep 2022 13:20:40 +0000

Beginning in Fall 2022, we are asking our Wyss community – our Faculty, staff, collaborators, partners, and external supporters – “If you could reimagine the world, what would it look like?” Every day Wyss members work to reimagine a world where anything is possible. It’s a world of scientific discovery, imagination, and reality, where diseases are cured, global warming is reversed…

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Landing therapeutic genes safely in the human genome

Jessica Leff — Mon, 24 Jan 2022 15:57:27 +0000

By Benjamin Boettner (BOSTON) — Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called “genomic safe harbors (GSHs).” These are landing sites in the human genome able to safely accommodate new therapeutic genes without causing other, unintended changes in a cell’s…

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Denitsa Milanova on MRBL – Gene Therapy for Skin Rejuvenation

Jessica Leff — Thu, 25 Mar 2021 14:45:11 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as scientists, and their collaborations at the Wyss Institute and beyond. When Denitsa Milanova was an engineering graduate student at Stanford University, she started taking business classes on the side to learn more about herself and her interests. She ended up with…

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MRBL: Next-Generation Gene Therapy for Molecular Skin Rejuvenation

admin — Sat, 13 Mar 2021 04:40:00 +0000

The skin is the largest organ in the body, and carries out multiple vital functions, including protective barrier functions against the loss of moisture and mechanical, UV and other injuries, immune defense functions, as well as sensory functions. For maintaining its integrity and multifaceted performances, skin relies on a range of different cell types that compose and support its layered…

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Improving Canine Healthspan

Jessica Leff — Thu, 06 Feb 2020 16:21:59 +0000

A Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University…

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Rejuvenate Bio launches to help dogs live longer, healthier lives

Jessica Leff — Thu, 06 Feb 2020 15:57:29 +0000

By Lindsay Brownell (BOSTON) — The Wyss Institute for Biologically Inspired Engineering at Harvard University announced today that Rejuvenate Bio has secured an exclusive worldwide license from the Harvard Office of Technology Development to commercialize a gene therapy technology developed at the Wyss Institute and Harvard Medical School (HMS) to prevent and treat several age-related diseases…

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