Wyss InstituteGenetics – Wyss Institute

The Dish Live with special guest George Church

Jessica Leff — Thu, 02 Jan 2025 15:24:53 +0000

In this very special live taping of “The Dish,” host Johannes Fruehauf sits down with renowned geneticist and Wyss Core Faculty member, George Church, Ph.D. Widely known for discovering the first direct genomic sequencing method, Church has reshaped the world of genetics. A professor at Harvard and MIT and a founding professor at the Wyss Institute, Church has co-founded over 50 startups—15+ of…

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SeqVerify: A New Easily Accessible Tool for Comprehensive Cell Line Quality Assessment – The Stem Cell Report

Jessica Leff — Thu, 12 Dec 2024 16:54:17 +0000

During the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biological questions. However, abnormalities in cell lines such as aneuploidy, mutations, on-target and off-target editing errors, and microbial contamination can arise during PSC culture or due to undesired editing outcomes.

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CRISPR’s Impact, Today

Mariel Schoen — Mon, 21 Oct 2024 12:00:08 +0000

By Seth Kroll (BOSTON) — In the not-so-distant past, CRISPR, the revolutionary gene-editing technology, was discovered as a defense system protecting bacteria against viruses. Today, with the persistence and ingenuity of many scientists, it is no longer just the subject of fascinating academic research papers and speculative discussions on its future usefulness for medicine.

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“Suspended animation” drug could aid organ transplantation and survival from traumatic injury

Jessica Leff — Tue, 24 Sep 2024 14:50:33 +0000

(CAMBRIDGE, UK) – Researchers have shown that a non-addictive pain relief drug could be used to preserve cells and organs quickly and safely for transplantation, removing the need for static cold storage. The research, published today in eLife, was described by the editors as an important study providing solid evidence that the existing drug, SNC80, can rapidly and reversibly slow biochemical…

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Alex Plesa on Reversing Aging

Jessica Leff — Thu, 30 May 2024 13:00:18 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. Most people believe that declining health as we age is an unfortunate, inevitable fact of life – but not Alex Plesa. He thinks the reason we think we can’t change it is because we don’t…

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Engineered Live Biotherapeutic Product (eLBP) to Protect the Microbiome from Antibiotics

Jessica Leff — Wed, 01 May 2024 14:44:43 +0000

Antibiotics not only kill the pathogenic bacteria causing an infection, they also indiscriminately wreak havoc on the trillions of “good” bacteria making up the human microbiome. Known as “dysbiosis,” this alteration of our gut microbial composition manifests as discomforting diarrhea in up to 35% of patients in the short term, and can take months to resolve, often requiring dietary corrections…

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Paper-Based Diagnostics

admin — Wed, 01 May 2024 00:34:41 +0000

With the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient care. This new type of…

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HarborSite Animation

Jessica Leff — Mon, 18 Mar 2024 13:59:40 +0000

This animation explains how the Wyss Institute’s HarborSite genome editing technology uses highly specific and efficient recombinase enzymes and genomic safe harbors to achieve more predictable, safe, and durable gene therapies. Credit: Wyss Institute at Harvard University…

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Highly Cited Researchers 2023 honors 13 Wyss faculty members

Jessica Leff — Wed, 15 Nov 2023 14:00:32 +0000

By Lindsay Brownell (BOSTON) — Today, Clarivate Analytics announced its annual Highly Cited Researchers 2023 list, which honors the top 1% of researchers around the world whose papers have been cited the most in the previous 10 years. Clarivate uses both quantitative and qualitative analyses to identify individuals who have demonstrated significant and broad influence in their chosen field(s)…

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Probiotic pills packed with an unexpected punch

Jessica Leff — Mon, 23 Oct 2023 17:14:14 +0000

By Jessica Leff Elite athletes are as rare as centenarians: both groups make up about 0.01% of the human population. This begs the question: what is unique about these super performers/the super fit, and can we use that information to improve the health of all humans throughout their lifespan? That was the central idea behind the sports genomics project at the Wyss Institute…

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