Wyss InstituteStem Cell Engineering – Wyss Institute

A model of Collaborative Ethics to guide translational research from fundamental discoveries to real-world applications

Jessica Leff — Tue, 25 Jun 2024 14:55:06 +0000

By Benjamin Boettner (BOSTON) — In sciences, disruptive research that is breaking new ground often raises new and not-yet-explored ethical questions. Although new scientific breakthroughs can have the power to change how we understand and live in the world, the ethical implications of technologies that will emerge based on these new insights can affect an emerging field’s public acceptance and…

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Wyss Institute’s CircaVent team awarded grant from BD2 to advance research into bipolar disorder and development of more effective drugs

Jessica Leff — Tue, 03 Oct 2023 14:56:09 +0000

By Benjamin Boettner (Boston) — The Wyss Institute’s CircaVent project will be supported by Breakthrough Discoveries for thriving with Bipolar Disorder (BD2), which aims to advance scientific understanding of the causes underlying bipolar disorder (BD). The CircaVent project examines the molecular mechanisms of common bipolar interventions and the pathophysiology of bipolar disorder to…

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Adding immunity to human kidney-on-a-chip advances cancer drug testing

Seth Kroll — Wed, 23 Aug 2023 14:57:37 +0000

By Benjamin Boettner (Boston) — A growing repertoire of cell and molecule-based immunotherapies is offering patients with indomitable cancers new hope by mobilizing their immune systems against tumor cells. An emerging class of such immunotherapeutics, known as T cell bispecific antibodies (TCBs), are of growing importance with several TCBs that the U.S. Food and Drug Administration (FDA)…

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Aric Lu on Breaking Biology by Bioprinting Complex Tissue

Jessica Leff — Thu, 18 May 2023 15:06:04 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as scientists, and their collaborations at the Wyss Institute and beyond. Like each cell in the body, each paddler in a dragon boat plays a specific role. In both cases, each has different characteristics and strengths, but all must work together in tandem for the…

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Reimagining Infertility – An Interview with Christian Kramme

Jessica Leff — Tue, 28 Mar 2023 14:12:12 +0000

Christian Kramme imagines a world where all people can have a child on their own time frame. Such “reproductive autonomy” is not the case today – infertility is a growing problem worldwide, and existing treatments like IVF are incredibly taxing on women’s bodies and too expensive for most of the global population to access. Listen to our interview with Christian to learn how he is working to turn…

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Reimagining Infertility – An Interview with Christian Kramme

Seth Kroll — Tue, 28 Mar 2023 14:11:15 +0000

By Lindsay Brownell Every day, members of the Wyss community reimagine a world where anything is possible. It’s a world of scientific discovery, imagination, and innovation, where diseases are cured, climate change is reversed, pandemics are prevented, and lives are changed for the better. The ideas that we are bringing to life through our research and engineering might seem like science fiction…

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A major step forward for organ biofabrication

Jessica Leff — Wed, 13 Jul 2022 14:00:18 +0000

By Leah Burrows / SEAS Communications (CAMBRIDGE, Mass.) ‑ Heart disease — the leading cause of death in the U.S. — is so deadly in part because the heart, unlike other organs, cannot repair itself after injury. That is why tissue engineering, ultimately including the wholesale fabrication of an entire human heart for transplant, is so important for the future of cardiac medicine.

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Getting to the heart of engineering a heart

Jessica Leff — Wed, 08 Jun 2022 14:58:05 +0000

By Benjamin Boettner (BOSTON) — Heart disease is the leading cause of death among adults and infants in the U.S. with about 659,000 people dying from heart disease each year, every one in four deaths. Among the many patients with a critical heart condition, about 3,500 are waiting for a heart transplant. Many of them will wait for more than six months, and for some of them time will run out…

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Programming complex tissue organizations in 3D

Jessica Leff — Tue, 10 May 2022 12:58:35 +0000

By Benjamin Boettner (BOSTON) — Tissue engineers have developed a variety of approaches to recreate organs and tissues de novo outside the human body for use in regenerative therapies, drug screening, and disease modeling. As two prominent examples, human “organoids” are being assembled from cells to form tiny artificial constructs in a dish that resemble human organs and larger human tissues…

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Harvard University licenses kidney engineering technology to Trestle Biotherapeutics to facilitate new kidney replacement therapies

Jessica Leff — Tue, 22 Feb 2022 18:57:14 +0000

By Benjamin Boettner (BOSTON/CAMBRIDGE, Mass.) — A newly launched startup is building upon innovations developed over several years at the Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard John A. Paulson School of Engineering & Applied Sciences (SEAS), and Brigham and Women’s Hospital (Brigham) to engineer functional kidney tissue for renal repair and…

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