Wyss InstituteBiomarker – Wyss Institute

Collaborative asthma project between Brigham and Women’s Hospital and the Wyss Institute advances with new grant support

Jessica Leff — Mon, 16 Dec 2024 15:55:41 +0000

By Benjamin Boettner (BOSTON) – Asthma affects more than 260M people worldwide and nearly 28M people in the U.S. alone, where, on average, 10 people die from attacks of the chronic disease each day. Many of these deaths could be prevented if patients had timely access to the appropriate therapy following an accurate diagnosis. Driven by an acute sense of urgency to close this diagnostic gap…

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Closing in on Parkinson’s Disease proteins in extracellular vesicles in the blood

Jessica Leff — Fri, 01 Nov 2024 13:20:38 +0000

By Benjamin Boettner (BOSTON) — Brain disorders like Parkinson’s (PD) or Alzheimer’s Disease (AD) start to develop in patients much earlier than when their first clinical symptoms appear. Treating patients at these early stages could slow or even stop their disease, but there is currently no way to diagnose brain disorders at those pre-symptomatic stages. Thus far, the specific brain lesions…

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Starting a fluorescent biosensor revolution

Mariel Schoen — Thu, 05 Sep 2024 09:00:00 +0000

By Benjamin Boettner (BOSTON) — Biosensors – devices that use biological molecules to detect the presence of a target substance – have enormous potential for detecting disease biomarkers, molecules-in-action in diverse biological processes, or toxins and other harmful substances in the environment. One of the more common types, fluorescent biosensors, consists of a target-binding biomolecule…

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ACE-ing protein detection in single cells

Jessica Leff — Tue, 30 Jul 2024 14:55:40 +0000

By Benjamin Boettner (BOSTON) — Since the 1950s, researchers have used a famous method invented by Wallace Coulter known as “flow cytometry” to characterize different types of immune cells in research studies and in blood samples from human individuals. This has enabled a much deeper understanding of immune cell development as well as new ways to assess human health and diagnose various blood…

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Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics

Jessica Leff — Wed, 01 May 2024 09:34:25 +0000

Speed, accuracy, and affordability are of the essence in the detection of established and newly emerging pathogens to provide timely care, mitigate transmission, and help lower the financial burden on healthcare systems. Among them, those causing sexually transmitted diseases (STIs), including HIV/AIDS and hepatitis C, cause a major global burden on health care systems. In the U.S. alone…

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Advancing precision diagnostics at the patient point-of-care

Jessica Leff — Thu, 08 Feb 2024 15:55:59 +0000

By Benjamin Boettner (BOSTON) — Aging populations and the tendency to lead a more sedentary lifestyle in many parts of the world is thought to dramatically increase the numbers of people living with multiple, chronic conditions. Moreover, climate change, as well as shifting patterns in land-use and travel, keep increasing the risk of infectious diseases that can emerge and spread locally and…

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Extracellular Vesicles for Biomarker Detection

Mariel Schoen — Wed, 24 Jan 2024 22:09:57 +0000

The Walt lab has developed an assay and platform to collect novel biomarkers in the form of extracellular vesicles (EVs) released from cells. As a result, a wider variety of EVs with unmatched quality, quantity, and purity can be obtained. EVs hold incredible value for the scientific and medical communities, as they can provide a better understanding of how disease starts in organs and tissues…

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Announcing the 2024 “Faculty Focus” List

Mariel Schoen — Wed, 24 Jan 2024 22:05:49 +0000

This year, we’re excited to announce our first-ever Wyss Faculty Focus list. We asked our world-class faculty which of their technologies they’re most excited about getting out of the lab and into the real world, and they’ve chosen the ones below. If you’re interested in collaborating, licensing, or otherwise getting involved with any of these technologies, please reach out to their respective…

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Novel test holds promise for detecting Parkinson’s disease early

Jessica Leff — Wed, 10 Jan 2024 20:05:14 +0000

By Haley Bridger/Brigham and Women’s Hospital communications and Benjamin Boettner/Wyss Institute communications (BOSTON) — In the development of Parkinson’s disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms. But without a test that can detect these changes, it’s impossible to intervene early to more effectively slow…

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Brigham-Wyss DxA

Mariel Schoen — Tue, 31 Oct 2023 18:01:32 +0000

The Wyss DxA’s clinical partners from Brigham and Women’s Hospital identify the most pressing unmet diagnostic needs, provide access to high-quality patient samples for our Biomarker Discovery Laboratory (BDL) and Brigham-Wyss DxA collaborators, and provide invaluable feedback and guidance on the engineering and validation of cost-effective, sensitive, and specific diagnostic tests.

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