Wyss InstituteCell Therapy – Wyss Institute

Innovative tissue engineering: ESCAPE, a pioneering new method explained

Jessica Leff — Wed, 11 Dec 2024 16:00:31 +0000

By Boston University Communications (BOSTON) — When it comes to the human body, form and function work together. The shape and structure of our hands enable us to hold and manipulate things. Tiny air sacs in our lungs called alveoli allow for air exchange and help us breath in and out. And tree-like blood vessels branch throughout our body, delivering oxygen from our head to our toes.

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ESCAPE Bioengineering

Jessica Leff — Wed, 11 Dec 2024 16:00:06 +0000

A research team at the Wyss Institute and Boston University has developed ESCAPE, the first method that enables the engineering of tissues across multiple length scales, ranging from the diameter of a cell to the cm scale of a heart valve. Credit: Wyss Institute at Harvard University…

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Wyss Institute’s iNodes team receives ARPA-H Sprint for Women’s Health award to advance the first implantable immune organs to treat ovarian cancer

Jessica Leff — Tue, 12 Nov 2024 14:58:41 +0000

By Benjamin Boettner (BOSTON) — Ovarian cancer is more deadly than any other type of female reproductive organ cancer. It is estimated that in 2024, in the U.S. alone, more than 12,000 women will die from the disease because available therapies are not effective. To help overcome this striking deficit in women’s health, ARPA-H has selected a team at the Wyss Institute at Harvard University as…

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Wyss Institute team selected by DARPA-SHIELD program to develop first-of-its-kind biologically engineered broad-spectrum antimicrobial therapeutic

Jessica Leff — Mon, 16 Sep 2024 13:25:50 +0000

By Benjamin Boettner (BOSTON) — Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University received a contract for up to $12M from the Defense Advanced Research Projects Agency (DARPA)’s new SHIELD program. The SHIELD (Synthetic Hemo-technologies to Locate and Disinfect) program aims to develop a prophylactic treatment that can be broadly administered to…

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Vinny Chandran Suja on Making Backpacks More Reliable and Predictable

Jessica Leff — Tue, 20 Aug 2024 13:10:41 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. As a kid, Vinny Chandran Suja had no interest in biology. Instead, his math and science acumen led him to pursue degrees in mechanical and chemical engineering, studying non-living systems.

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Boosting CAR-T cell therapies from under the skin

Jessica Leff — Wed, 12 Jun 2024 13:15:07 +0000

By Benjamin Boettner (BOSTON) — CAR-T cell therapies are transforming the treatment of previously incurable blood cancers. Six approved CAR-T products have been administered to more than 20,000 people, and more than 500 clinical trials are underway. However, according to a recent study out of the Massachusetts General Hospital, among 100 patients suffering from lymphomas, myelomas or B-cell…

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The Wyss Institute’s 2024-2025 Validation Projects

Jessica Leff — Wed, 29 May 2024 14:55:23 +0000

Every year the Wyss Institute names a class of Validation Projects whose teams receive dedicated funding, business development support, and other resources to advance their promising technologies towards commercialization. They also collaborate with key opinion leaders, investors, and potential customers to de-risk their innovations and speed their progress to the market. This year…

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Metabolically Labeled CAR-T Cells Against Cancer

Jessica Leff — Wed, 01 May 2024 17:03:45 +0000

In recent years, adoptive T cell therapies like CAR-T cell therapy – in which T cells are obtained from a patient, genetically enhanced ex vivo, and infused back into the same patient – have shown spectacular success in the treatment of blood cancers, including leukemias, lymphomas, and more lately multiple myelomas. However, not all patients with a given blood cancer benefit equally from this…

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Ichor: Reversing Aging

Jessica Leff — Wed, 01 May 2024 10:47:33 +0000

More than 150,000 people die each day across the globe, about two-thirds of them from age-related causes like cancer, neurodegenerative diseases, and cardiovascular disease. If the process of aging could be slowed or reversed, the incidence of these conditions would be dramatically reduced, and more humans would live longer, healthier lives. However, aging is a complex process involving multiple…

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Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More

admin — Tue, 30 Apr 2024 20:33:51 +0000

Macrophages are the body’s multipurpose defense agents, patrolling for pathogens and engulfing cellular debris, foreign substances, microbes, and even cancer cells. But cancerous tumors have evolved an insidious defense mechanism: they can switch arriving macrophages from an active, pro-inflammatory state to a passive, anti-inflammatory state, in which they actually promote the tumor’s growth.

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