Wyss InstituteDrug Development – Wyss Institute

Innovative tissue engineering: ESCAPE, a pioneering new method explained

Jessica Leff — Wed, 11 Dec 2024 16:00:31 +0000

By Boston University Communications (BOSTON) — When it comes to the human body, form and function work together. The shape and structure of our hands enable us to hold and manipulate things. Tiny air sacs in our lungs called alveoli allow for air exchange and help us breath in and out. And tree-like blood vessels branch throughout our body, delivering oxygen from our head to our toes.

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ESCAPE Bioengineering

Jessica Leff — Wed, 11 Dec 2024 16:00:06 +0000

A research team at the Wyss Institute and Boston University has developed ESCAPE, the first method that enables the engineering of tissues across multiple length scales, ranging from the diameter of a cell to the cm scale of a heart valve. Credit: Wyss Institute at Harvard University…

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CRISPR’s Impact, Today

Mariel Schoen — Mon, 21 Oct 2024 12:00:08 +0000

By Seth Kroll (BOSTON) — In the not-so-distant past, CRISPR, the revolutionary gene-editing technology, was discovered as a defense system protecting bacteria against viruses. Today, with the persistence and ingenuity of many scientists, it is no longer just the subject of fascinating academic research papers and speculative discussions on its future usefulness for medicine.

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Eliz Amar Lewis on Using Many Tools to Fight a Sophisticated Disease

Jessica Leff — Tue, 24 Sep 2024 14:50:19 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. Eliz Amar Lewis has always been fascinated by biology. But when she saw her grandmother bravely battle breast cancer, she was inspired to use her passion to develop a smart and sophisticated…

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Ropirio: Novel Treatments Targeting the Lymphatic System

Mariel Schoen — Wed, 11 Sep 2024 13:56:37 +0000

The human lymphatic system is vast and critical to our health, including the proper functioning of our immune system. Over the last decade, research into the lymph system has revealed its dysfunction in a wide variety of diseases, but development of drugs to directly target the lymph system has lagged, in part because there are few reliable preclinical models of lymph vessels on which to test drug…

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Ropirio launches from Wyss Institute to develop first-in-class lymphatic medicines

Mariel Schoen — Wed, 11 Sep 2024 13:55:12 +0000

By Lindsay Brownell (BOSTON) — The Wyss Institute at Harvard University announced today that Ropirio Therapeutics, Inc. (Ropirio) has secured a worldwide, exclusive license from Harvard’s Office of Technology Development (OTD) and Boston University (BU)’s Technology Development office for novel molecules that activate the lymphatic system – a first in the pharma industry. “There has been a…

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Starting a fluorescent biosensor revolution

Mariel Schoen — Thu, 05 Sep 2024 09:00:00 +0000

By Benjamin Boettner (BOSTON) — Biosensors – devices that use biological molecules to detect the presence of a target substance – have enormous potential for detecting disease biomarkers, molecules-in-action in diverse biological processes, or toxins and other harmful substances in the environment. One of the more common types, fluorescent biosensors, consists of a target-binding biomolecule…

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Alzheimer’s drug may someday help save lives by inducing a state of “suspended animation”

Jessica Leff — Thu, 22 Aug 2024 15:25:07 +0000

By Lindsay Brownell (BOSTON) — Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University report that they were able to successfully put tadpoles of Xenopus laevis frogs into a hibernation-like torpor state using donepezil (DNP), a drug approved by the FDA to treat Alzheimer’s. The team had previously used another drug, SNC80, to achieve similar results in…

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Wyss Institute Research Collaboration Awarded ARPA-H Agreement to Develop Disease-Agnostic Immunotherapeutic RNA Platform

Jessica Leff — Mon, 15 Jul 2024 14:55:26 +0000

By Benjamin Boettner With the award for up to $27M from the Advanced Research Projects Agency for Health (ARPA-H), a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

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AminoX: Making Better Protein Drugs, Quicker and Cheaper

Jessica Leff — Wed, 10 Jul 2024 13:56:00 +0000

A synthetic biology and advanced chemistry platform that efficiently incorporates non-standard amino acids by hacking the ubiquitous protein synthesis process. Credit: Wyss Institute at Harvard University…

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