Wyss InstituteOrgans on Chips – Wyss Institute

“Suspended animation” drug could aid organ transplantation and survival from traumatic injury

Jessica Leff — Tue, 24 Sep 2024 14:50:33 +0000

(CAMBRIDGE, UK) – Researchers have shown that a non-addictive pain relief drug could be used to preserve cells and organs quickly and safely for transplantation, removing the need for static cold storage. The research, published today in eLife, was described by the editors as an important study providing solid evidence that the existing drug, SNC80, can rapidly and reversibly slow biochemical…

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Ropirio: Novel Treatments Targeting the Lymphatic System

Mariel Schoen — Wed, 11 Sep 2024 13:56:37 +0000

The human lymphatic system is vast and critical to our health, including the proper functioning of our immune system. Over the last decade, research into the lymph system has revealed its dysfunction in a wide variety of diseases, but development of drugs to directly target the lymph system has lagged, in part because there are few reliable preclinical models of lymph vessels on which to test drug…

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Ropirio launches from Wyss Institute to develop first-in-class lymphatic medicines

Mariel Schoen — Wed, 11 Sep 2024 13:55:12 +0000

By Lindsay Brownell (BOSTON) — The Wyss Institute at Harvard University announced today that Ropirio Therapeutics, Inc. (Ropirio) has secured a worldwide, exclusive license from Harvard’s Office of Technology Development (OTD) and Boston University (BU)’s Technology Development office for novel molecules that activate the lymphatic system – a first in the pharma industry. “There has been a…

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Wyss Institute Research Collaboration Awarded ARPA-H Agreement to Develop Disease-Agnostic Immunotherapeutic RNA Platform

Jessica Leff — Mon, 15 Jul 2024 14:55:26 +0000

By Benjamin Boettner With the award for up to $27M from the Advanced Research Projects Agency for Health (ARPA-H), a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

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Human cervix modeled in microfluidic organ chip fills key women’s health gap

Jessica Leff — Fri, 31 May 2024 14:55:29 +0000

By Benjamin Boettner (BOSTON) — Bacterial Vaginosis (BV) has been identified as one of the many unmet needs in women’s health and affects more than 25% of reproductive-aged women. It is caused by pathogenic bacteria that push the healthy microbiomes in the female vagina and cervix – the small gatekeeper canal that connects the uteruns and vagina – into a state of imbalance known as dysbiosis.

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Mice Don’t Menstruate: Reimagining Women’s Health Using Organ Chips with Dr. Donald Ingber

Jessica Leff — Wed, 08 May 2024 13:05:03 +0000

In this episode, host Sharon Kedar, Co-Founder of Northpond Ventures, is joined by Dr. Donald Ingber, Founding Director at Wyss Institute for Biologically Inspired Engineering at Harvard University. Dr. Ingber’s commitment to following his passion has led him to countless medical and technological breakthroughs, including Organ Chip technology. These incredible chips recreate the structure and…

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Atlantic Health Research Spotlight: Female-Reproductive-Tract Organ Chips for Women’s Health and Fertility Studies

Jessica Leff — Thu, 11 Apr 2024 19:34:29 +0000

Innovation has disrupted care as we know it. Challenges with access, complex diseases, and care delivery persist, but so do areas of opportunity for emerging tech and discoveries. The Atlantic explored gene editing, artificial intelligence, climate change, weight-loss and diabetes treatments, and more at their annual Health Summit. Wyss researchers Aakanksha Gulati, Ph.D., and Ola Gutzeit, Ph.D.

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Ola Gutzeit on Improving Fertility

Jessica Leff — Tue, 26 Mar 2024 13:54:21 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. As a reproductive health specialist in the clinical setting, Ola Gutzeit discovered a lack of effective methods for enhancing fertility care. Driven by a constant desire to seek innovative…

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Bogdan Budnik on Analyzing Proteins to Develop Better Diagnostics and Therapeutics

Jessica Leff — Thu, 15 Feb 2024 14:50:30 +0000

The Humans of the Wyss (HOW) series features members of the Wyss community discussing their work, the influences that shape them as professionals, and their collaborations at the Wyss Institute and beyond. After studying physics for many years, Bogdan Budnik realized instead of using his knowledge to generate power, he wanted to use it to empower people with better disease diagnostics and…

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Making Sugar Healthier – DDN Dialogues

Jessica Leff — Wed, 31 Jan 2024 14:33:15 +0000

With some out-of-the-box engineering, researchers have developed a nature-inspired strategy to turn sugar in packaged foods into gut-healthy fiber. This podcast features Director of Business Development, Sam Inverso, Ph.D., and Senior Engineer Adama Sesay, Ph.D., along with Judith Moca and John Topinka from Kraft-Heinz. This episode was created and is owned by Drug Discovery News…

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